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A journal cohort study in Singapore which published by Elsevier (nutrition 79-80 (2020) 111017) to evaluate the effect of vitamin D, Magnesium and vitamin B12 (DMB) in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)
□Study Objective : To determine clinical outcomes of older patients with Coronavirus (Covid-19) who received oral combination of 1000iu/d Vitamin D, 150 mg/d Magnesium and 500mcg/d Vitamin B12
□Subject: Total of 43 patients age ≥50.
17 received treatment VS 26 without treatment
□Duration: 15/1/2020 – 15/4/2020
□Clinical outcomes: Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the treatment group retained protective significant. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5% P=0.0006).